Tissues undergo damage due to various factors like disease, injury, ageing and need to be repaired and regenerated. The body is unable to always repair and regenerate tissues. In such cases, an instruction and boost to the body would help in regeneration.
TherageniX uses proprietary technology to deliver genes which can instruct the body to produce relevant proteins or factors that help in tissue regeneration.
While any tissue can be targeted using the technology, TherageniX will focus on orthopaedic applications first. There are over 4M bone grafting procedures performed globally. The transplantation of autologous bone is still the gold standard bone repair strategy.
However, this process still has drawbacks in terms of limited availability of autologous bone for large defects, in patients with diseased bone, additional trauma and infection risk at the harvesting site and insufficient regenerative capacity.
Many bone implants fail due to rejection, infection, or fail to provide satisfactory functionality and regeneration.
With Theragenix’s innovative solution, we will be able to augment autologous bone grafts intra-operatively by delivering gene(s) of interest using a proprietary non-viral delivery system. This helps improve regenerative capacity and is expected to lead to better functional outcomes while reducing the additional trauma at the donor site.
TherageniX’s technology uses a proprietary non-viral delivery system with desired regenerative factor genes (e.g. VEGF, BMP; for vascularization and osteogenesis, respectively) and autologous bone marrow cells from the patient.
The gene(s) of interest are delivered to the patient’s cells outside the body. After transfection, the cells along with autograft material are implanted at the graft site. This intra-operative procedure is not expected to add additional time to the surgery.
The technology has been licensed from University of Nottingham. TherageniX is very excited to collaborate with Dr. James Dixon’s group to improve the science and technology further and to translate this work into therapies for patients.
News from TherageniX
Job Title Scientific Project Manager Job Type Fixed-Term 1 year (with possibility of extension), Full-time Hours per week 37.5 per week Location Remote with occasional
TherageniX and University of Nottingham Awarded £995K Innovate UK Grant to Develop Powdered Gene Therapy for Bone Regeneration
London, UK, and Nottingham, UK, 31 August 2023: TherageniX, a University of Nottingham spin out pioneering a dry powder gene therapy formulation for bone graft
Our partner, U of N also shared their perspective on the launch of TherageniX, a spin-out company – TherageniX to deliver gene therapy as part of bone repair
Disease, injuries and aging can damage body tissues. There is an unmet need for novel therapies to enable tissue repair and regeneration. The use of